Jerome V. Braun is the principal of Kings Mountain Research, located in Woodside, California, centrally located between Silicon Valley and Biotech Bay. He specializes in mathematical and statistical consulting and analysis in the biotechnology and high-technology industries, emphasizing the translation of business needs into practical solutions.

Dr. Braun consulted, performed research, and taught at the University of California at Davis during his dissertation research. At Genentech, Inc. from 1995 to 1998, he developed further expertise in software development, statistical programming, biotechnology consulting, and analysis of Phase I clinical trials while in the departments of Biostatistics and of Scientific Computing. As founder of Kings Mountain Research, he has focussed on the application of statistical algorithms and theory to diverse projects, including financial market technical analysis and DNA sequence analysis.

Several interesting projects highlight Dr. Braun's expertise:

• Developed The Perl Program Trading Kit, an open-source framework for developing, testing, and operating trading systems.
• Developed Finance::Options, a Perl module for conducting option pricing and related calculations, facilitating development of an on-line trading system.
• Developed a validated web-based data reporting system for assay technicians, which reduced the time spent reporting experimental results from four hours to 10 minutes.
• Developed a numerical model and a web-based interface to provide assay developers with the ability to predict the effects of multiple binding proteins.
• Developed a calibration model for FACS analysis, allowing technicians to switch between machines in mid-experiment, preventing loss of experimental data in cases when machines went down.

Dr. Braun was awarded a Doctoral degree in statistics from the University of California at Davis, as well as Masters degrees in genetics and statistics; he also holds a Masters degree in mathematics from San Francisco State University. He is a member of the American Statistical Association and the American Association for the Advancement of Science.

Publications

Braun, J.V., Braun, R.K., and Müller, H.-G. (2000) Quasi-likelihood fitting of multiple change-points, with application to DNA sequence segmentation. (To be published in Biometrika.)

Braun, J.V. and Müller, H.-G. (1998) Statistical methods for DNA sequence segmentation. Statistical Science 13:2, 142-162.

2000 - Data Analysis, Modeling, and Visualization for Bioinformatics at the University of California Extension, Santa Cruz, CA. (Course will start in September 2000.)

1997 - Statistical Aspects of Pharmacokinetics (with Dr. James Reimann) at the Department of Biostatistics, Genentech, Inc., South San Francisco, CA.

This course provided twelve biostatisticians with sufficient background to handle routine analysis of Phase I clinical trials.

1994 - Statistics 32: Basic Statistical Analysis through Computers at the Division of Statistics, University of California, Davis, CA.

2000 - Bayesian Logic in Biotech, High-tech, and Finance at 21st Annual Institute on Research and Statistics, Sacramento Statistical Association, Sacramento, CA. (Invited by Hans-Georg Müller.)

1998 - The Next Step in Bioinformatics: Genetic Network Analysis at Applied Math Group, Genentech, Inc., South San Francisco, CA.

1998 - Maximum Likelihood for Changed Segments in Markov Chains and Applications to DNA Contamination Detection in Genomic Databases at Applied Math Group, Genentech, Inc., South San Francisco, CA.

1998 - Statistical Consulting in the Biotechnology Industry: An Overview at Division of Statistics, University of California, Davis, CA.

1998 - Statistics in the Biopharmaceutical Business: Some Lessons Learned at Statistics Graduate Seminar, University of California, Davis, CA.

1997 - Bayesian Analysis of Preclinical Data at Joint Statistical Meetings, Anaheim, CA. (Invited by Donald Berry.)

1997 - Manufacturing Proteins through Recombinant Technology at Midwest Biopharmaceutical Statistics Workshop, Muncie, IA. (Invited by David Giltinan.)

1996 - Bayesian Statistics in Phase I Clinical Trials at Department of Biostatistics, Genentech, Inc., South San Francisco, CA.